Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Cancer cells disseminate and seed in distant organs, where they can remain dormant for
many years before forming clinically detectable metastases. Here we studied how …

Ki67 staining is widely used as a proliferation indicator in the clinic, despite poor
understanding of this protein's function or dynamics. Here, we track Ki67 levels under …

Mammalian genomes are spatially organized into compartments, topologically associating
domains (TADs), and loops to facilitate gene regulation and other chromosomal functions …

Summary N 6-methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing
and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus …

Summary The Cdk-Rb-E2F pathway integrates external and internal signals to control
progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway …

Inhibiting the cell-cycle kinases CDK4 and CDK6 results in significant therapeutic effect in
patients with advanced hormone-positive breast cancer. The efficacy of this strategy is …