Trailing TRAIL resistance: novel targets for TRAIL sensitization in cancer cells
Resistance to chemotherapeutic drugs is the major hindrance in the successful cancer
therapy. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of …
therapy. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of …
Epigenetics and cancer treatment
In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …
changes in gene expression not encoded by the DNA sequences, which are referred to as …
Enhancing the apoptotic and therapeutic effects of HDAC inhibitors
AJ Frew, RW Johnstone, JE Bolden - Cancer letters, 2009 - Elsevier
Histone deacetylase inhibitors (HDACi) are anti-cancer drugs that have moved rapidly
through clinical development and in 2006 vorinostat (SAHA, Zolinza) was given FDA …
through clinical development and in 2006 vorinostat (SAHA, Zolinza) was given FDA …
Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia
T Bhatla, J Wang, DJ Morrison, EA Raetz… - Blood, The Journal …, 2012 - ashpublications.org
Whereas the improvement in outcome for children with acute lymphoblastic leukemia has
been gratifying, the poor outcome of patients who relapse warrants novel treatment …
been gratifying, the poor outcome of patients who relapse warrants novel treatment …
Targeting extrinsic apoptosis in cancer: Challenges and opportunities
S Fulda - Seminars in cell & developmental biology, 2015 - Elsevier
Apoptosis is a form of programmed cell death that plays a critical role in the regulation of
various physiological and pathophysiological processes. Since apoptosis is typically …
various physiological and pathophysiological processes. Since apoptosis is typically …
Histone deacetylases and histone deacetylase inhibitors in neuroblastoma
M Phimmachanh, JZR Han, YEI O'Donnell… - Frontiers in cell and …, 2020 - frontiersin.org
Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene
expression by remodeling chromatin structure. An imbalance of histone acetylation caused …
expression by remodeling chromatin structure. An imbalance of histone acetylation caused …
TRAILing death in cancer
G Mellier, S Huang, K Shenoy, S Pervaiz - Molecular aspects of medicine, 2010 - Elsevier
The observation that certain types of cancer express death receptors on their cell surface
has triggered heightened interest in exploring the potential of receptor ligation as a novel …
has triggered heightened interest in exploring the potential of receptor ligation as a novel …
Development of histone deacetylase inhibitors for cancer treatment
D Marchion, P Münster - Expert review of anticancer therapy, 2007 - Taylor & Francis
Histone deacetylase (HDAC) inhibitors are an exciting new addition to the arsenal of cancer
therapeutics. The inhibition of HDAC enzymes by HDAC inhibitors shifts the balance …
therapeutics. The inhibition of HDAC enzymes by HDAC inhibitors shifts the balance …
Targeting the apoptosis pathway to treat tumours of the paediatric nervous system
MC Fitzgerald, PJ O'Halloran, NMC Connolly… - Cell Death & …, 2022 - nature.com
New, more effective therapeutics are required for the treatment of paediatric cancers.
Current treatment protocols of cytotoxic treatments including chemotherapy trigger cancer …
Current treatment protocols of cytotoxic treatments including chemotherapy trigger cancer …
The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells
Epidermal growth factor receptor (EGFR), which promotes cell survival and division, is found
at abnormally high levels on the surface of many cancer cell types, including many cases of …
at abnormally high levels on the surface of many cancer cell types, including many cases of …