Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery–a review for multidisciplinary researchers
Pulmonary drug delivery is the focus of much research and development because of its
great potential to produce maximum therapeutic benefit. Among the available options the dry …
great potential to produce maximum therapeutic benefit. Among the available options the dry …
Airway geometry, airway flow, and particle measurement methods: implications on pulmonary drug delivery
Introduction: The effectiveness of drug delivery to the lungs is inextricably linked to the
fundamental interactions that occur between particles and flow in the extrathoracic airway …
fundamental interactions that occur between particles and flow in the extrathoracic airway …
Flow abilities of powders and granular materials evidenced from dynamical tap density measurement
This paper offers an overview of the flow properties of granular systems, including voids,
granular porosity and random packing characteristics. For the purposes of the study, the …
granular porosity and random packing characteristics. For the purposes of the study, the …
Simulation of dry powder inhalers: combining micro‐scale, meso‐scale and macro‐scale modeling
B van Wachem, K Thalberg, J Remmelgas… - AIChE …, 2017 - Wiley Online Library
The flow of carrier particles, coated with active drug particles, is studied in a prototype dry
powder inhaler. A novel, multiscale approach consisting of a discrete element model (DEM) …
powder inhaler. A novel, multiscale approach consisting of a discrete element model (DEM) …
In-depth comparison of dry particle coating processes used in dpi particle engineering
N Bungert, M Kobler, R Scherließ - Pharmaceutics, 2021 - mdpi.com
High-shear mixer coatings as well as mechanofusion processes are used in the particle-
engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle …
engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle …
“Pierce and inhale” design in capsule based dry powder inhalers: Effect of capsule piercing and motion on aerodynamic performance of drugs
In this work three capsule-based dry powder inhalers, available for generics product
development, were compared. Two technologically different dry powder formulations were …
development, were compared. Two technologically different dry powder formulations were …
Development of a high efficiency dry powder inhaler: effects of capsule chamber design and inhaler surface modifications
Purpose The objective of this study was to explore the performance of a high efficiency dry
powder inhaler (DPI) intended for excipient enhanced growth (EEG) aerosol delivery based …
powder inhaler (DPI) intended for excipient enhanced growth (EEG) aerosol delivery based …
Development and comparison of new high-efficiency dry powder inhalers for carrier-free formulations
High-efficiency dry powder inhalers (DPIs) were developed and tested for use with carrier-
free formulations across a range of different inhalation flow rates. Performance of a …
free formulations across a range of different inhalation flow rates. Performance of a …
Detailed evaluation of drug powder deposition in swirl-type dry powder inhalers
M Sommerfeld - Powder Technology, 2022 - Elsevier
Based on numerical simulations by the Euler/Lagrange approach in combination with the
RNG-k-ε turbulence model flow field and particle transport through inhaler devices are …
RNG-k-ε turbulence model flow field and particle transport through inhaler devices are …
[HTML][HTML] A new LED-based extinction tomography method for measurement of aerosol surface area
A light-emitting-diode (LED) based optical technique is developed to measure the surface
area per unit volume of particles in aerosols and liquid sprays. The technique uses path …
area per unit volume of particles in aerosols and liquid sprays. The technique uses path …