The development and application of the free-electron X-ray laser (XFEL) to structure and
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …

X-ray free-electron lasers provide femtosecond-duration pulses of hard X-rays with a peak
brightness approximately one billion times greater than is available at synchrotron radiation …

This review is focused on free-electron lasers (FELs) in the hard to soft x-ray regime. The
aim is to provide newcomers to the area with insights into: the basic physics of FELs, the …

The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by
superconducting accelerator technology enables the measurement of significantly more …

With the emergence of X-ray free-electron lasers (XFELs), coherent diffractive imaging (CDI)
has acquired a capability for single-particle imaging (SPI) of non-crystalline objects under …

Cryo-EM, XFELs and the structure conundrum in structural biology | Nature Methods Skip to
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Crystallography has made a notable contribution to our knowledge of structural biology. For
traditional crystallography experiments, the growth of crystals with large size and high …

Single-particle diffraction from X-ray Free Electron Lasers offers the potential for molecular
structure determination without the need for crystallization. In an effort to further develop the …

Macromolecular crystallography was immensely successful in the last two decades. To a
large degree this success resulted from use of powerful third generation synchrotron x-ray …

Single particle imaging at x-ray free electron lasers (XFELs) has the potential to determine
the structure and dynamics of single biomolecules at room temperature. Two major hurdles …