Mechanisms controlling the mechanical properties of the nuclei
G Bastianello, M Foiani - Current Opinion in Cell Biology, 2023 - Elsevier
The mechanical properties of the nucleus influence different cellular and nuclear functions
and have relevant implications for several human diseases. The nucleus protects genetic …
and have relevant implications for several human diseases. The nucleus protects genetic …
BRG1: Promoter or suppressor of cancer? The outcome of BRG1's interaction with specific cellular pathways
A Shaykevich, I Silverman, G Bandyopadhyaya… - International journal of …, 2023 - mdpi.com
BRG1 is one of two catalytic subunits of the SWI/SNF ATP-dependent chromatin-remodeling
complex. In cancer, it has been hypothesized that BRG1 acts as a tumor suppressor. Further …
complex. In cancer, it has been hypothesized that BRG1 acts as a tumor suppressor. Further …
SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells
The packaging of DNA into chromatin plays an important role in transcriptional regulation
and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as BRG1), the …
and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as BRG1), the …
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …
[HTML][HTML] The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation
Cancer cells reprogram cellular metabolism to meet the demands of growth. Identification of
the regulatory machinery that regulates cancer-specific metabolic changes may open new …
the regulatory machinery that regulates cancer-specific metabolic changes may open new …
Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF
The highly conserved zinc finger CCCTC-binding factor (CTCF) regulates genomic
imprinting and gene expression by acting as a transcriptional activator or repressor of …
imprinting and gene expression by acting as a transcriptional activator or repressor of …
The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non‐cancer cells
Actomyosin stress fibers impinge on the nucleus and can exert compressive forces on it.
These compressive forces have been proposed to elongate nuclei in fibroblasts, and lead to …
These compressive forces have been proposed to elongate nuclei in fibroblasts, and lead to …
The histone variant H2A. Z and chromatin remodeler BRAHMA act coordinately and antagonistically to regulate transcription and nucleosome dynamics in …
ES Torres, RB Deal - The Plant Journal, 2019 - Wiley Online Library
Plants adapt to environmental changes by regulating transcription and chromatin
organization. The histone H2A variant H2A. Z and the SWI 2/SNF 2 ATP ase BRAHMA …
organization. The histone H2A variant H2A. Z and the SWI 2/SNF 2 ATP ase BRAHMA …
[HTML][HTML] SWI/SNF complexes are required for full activation of the DNA-damage response
SL Smith-Roe, J Nakamura, D Holley, PD Chastain… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract SWI/SNF complexes utilize BRG1 (also known as SMARCA4) or BRM (also known
as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel chromatin …
as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel chromatin …
The connection between BRG1, CTCF and topoisomerases at TAD boundaries
AR Barutcu, JB Lian, JL Stein, GS Stein, AN Imbalzano - Nucleus, 2017 - Taylor & Francis
The eukaryotic genome is partitioned into topologically associating domains (TADs). Despite
recent advances characterizing TADs and TAD boundaries, the organization of these …
recent advances characterizing TADs and TAD boundaries, the organization of these …