The function of G protein-coupled receptors (GPCRs) which represent the largest class of
both human membrane proteins and drug targets depends critically on their ability to …

The quantitative assessment of uncertainty and sampling quality is essential in molecular
simulation. Many systems of interest are highly complex, often at the edge of current …

Circadian rhythms are generated by complex interactions among genes and proteins. Self-
sustained∼ 24 h oscillations require negative feedback loops and sufficiently strong …

Several class-A G protein-coupled receptor (GPCR) proteins act as constitutive phospholipid
scramblases catalyzing the transbilayer translocation of> 10,000 phospholipids per second …

Rhodopsin, a prototypical G protein-coupled receptor, is a membrane protein that can sense
dim light. This highly effective photoreceptor is known to be sensitive to the composition of its …

G protein-coupled receptors are a large family of membrane proteins activated by a variety
of structurally diverse ligands making them highly adaptable signaling molecules. Despite …

Proteorhodopsin (PR) is a microbial proton pump that plays a significant role in phototrophy
of bacteria in marine environments. Fundamental understanding of the structure–function …

Rhodopsin is the key photoreceptor protein that mediates vision in low-light conditions.
Mutations in rhodopsin are the cause of retinal degenerative diseases such as retinitis …

The cannabinoid type 1 and 2 G-protein-coupled receptors are currently important
pharmacological targets with significant drug discovery potential. These receptors have …

The KDEL receptor (KDELR) is a trafficking receptor which is involved in the retrograde
trafficking of ER resident proteins that escaped to the Golgi. For this function, the receptor …