Abstract Systems analysis of metabolic and growth functions in microbial organisms is rapidly developing and maturing. Such studies are enabled by reconstruction, at the …
Gene co-expression networks can be used to associate genes of unknown function with biological processes, to prioritize candidate disease genes or to discern transcriptional …
Machine learning approaches offer the potential to systematically identify transcriptional regulatory interactions from a compendium of microarray expression profiles. However …
R Mahr, J Frunzke - Applied microbiology and biotechnology, 2016 - Springer
Living organisms have evolved a plethora of sensing systems for the intra-and extracellular detection of small molecules, ions or physical parameters. Several recent studies have …
F Mordelet, JP Vert - Pattern Recognition Letters, 2014 - Elsevier
We consider the problem of learning a binary classifier from a training set of positive and unlabeled examples, both in the inductive and in the transductive setting. This problem …
MA Kohanski, DJ Dwyer, J Wierzbowski, G Cottarel… - Cell, 2008 - cell.com
Aminoglycoside antibiotics, such as gentamicin and kanamycin, directly target the ribosome, yet the mechanisms by which these bactericidal drugs induce cell death are not fully …
DJ Dwyer, MA Kohanski, B Hayete… - Molecular systems …, 2007 - embopress.org
Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase‐catalyzed strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic …
O Mason, M Verwoerd - IET systems biology, 2007 - IET
A survey of the use of graph theoretical techniques in Biology is presented. In particular, recent work on identifying and modelling the structure of bio-molecular networks is …
P D'haeseleer - Nature biotechnology, 2006 - nature.com
Sequence motifs are becoming increasingly important in the analysis of gene regulation. How do we define sequence motifs, and why should we use sequence logos instead of …