Unraveling the secrets: evolution of resistance mediated by membrane proteins

X Yang, M Li, ZC Jia, Y Liu, SF Wu, MX Chen… - Drug Resistance …, 2024 - Elsevier
Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields
such as medicine, agriculture, and environmental science. Understanding its complexity and …

[HTML][HTML] Environmental antimicrobial resistance: implications for food safety and public health

OV Ifedinezi, ND Nnaji, CK Anumudu, CT Ekwueme… - Antibiotics, 2024 - mdpi.com
Antimicrobial resistance (AMR) is a serious global health issue, aggravated by antibiotic
overuse and misuse in human medicine, animal care, and agriculture. This study looks at …

Salmonella: Infection mechanism and control strategies

J Lu, H Wu, S Wu, S Wang, H Fan, H Ruan, J Qiao… - Microbiological …, 2024 - Elsevier
Salmonella is a foodborne pathogen that predominantly resides in the intestinal tract of
humans and animals. Infections caused by Salmonella can lead to various illnesses …

Computational studies on metabolic pathways of Coxiella burnetii to combat Q fever: A roadmap to vaccine development

A Sharma, S Kumar, R Kumar, AK Sharma, B Singh… - Microbial …, 2025 - Elsevier
Coxiella burnetii (Cbu) is the gram-negative intracellular pathogen responsible for deadly
zoonotic infection, Q fever. The pathogen is environmentally stable and distributed …

Monoclonal Antibodies as a Therapeutic Strategy against Multidrug-Resistant Bacterial Infections in a Post-COVID-19 Era

HC Chen, YL Pan, Y Chen, TH Yang, ET Hsu… - Life, 2024 - mdpi.com
The development of severe multidrug-resistant bacterial infections has recently intensified
because of the COVID-19 pandemic. According to the guidelines issued by the World Health …

Exposure to imipenem at sub-minimum inhibitory concentration leads to altered expression of major outer membrane proteins in Acinetobacter baumannii

S Nayak, SD Akshay, VK Deekshit… - Journal of Applied …, 2024 - academic.oup.com
Aims Acinetobacter baumannii is a nosocomial pathogen known to be multidrug-resistant
(MDR), especially to drugs of the carbapenem class. Several factors contribute to resistance …

Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening

JW Powell, CA Mann, PD Toth, S Nolan… - ACS Medicinal …, 2024 - ACS Publications
Multidrug-resistant bacterial infections pose an ever-evolving threat to public health. Since
the outset of the antibacterial age, bacteria have developed a multitude of diverse resistance …

Revolutionizing Infection Control: Harnessing the Power of Stem Cells for Precision Antimicrobial Therapy

A Dey, PK Sharma, A Pathak, SK Yadav… - Emerging Paradigms for …, 2024 - Springer
As antibiotic resistance spreads, infectious illnesses continue to represent a major danger to
human health, emphasizing the urgent need for novel and targeted treatment methods. Stem …

A novel member of drug/metabolite transporter (DMT) family efflux pump, SA00565, contributes to tetracycline antibiotics resistance in Staphylococcus aureus …

D Li, Y Ge, N Wang, Y Shi, G Guo, J Zhang… - Microbiology …, 2024 - Am Soc Microbiol
Drug efflux systems have recently been recognized as a significant mechanism responsible
for multidrug resistance in bacteria. In this study, we described the identification and …

Computational Evaluation of Fusarium nygamai Compounds as AcrD Efflux Pump Protein Inhibitors of Salmonella Typhimurium

LI Garrido-Palazuelos, JR Aguirre-Sánchez… - Molecular …, 2024 - Springer
Abstract In Salmonella Typhimurium, efflux pump proteins, such as AcrD actively expel
drugs and hazardous chemicals from bacterial cells, resulting in treatment failure and the …