Pediatric cardiomyopathies (CMs) and electrical diseases constitute a heterogeneous
spectrum of disorders distinguished by structural and electrical abnormalities in the heart …

The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel
RyR2 is an essential regulator of cardiac excitation–contraction coupling and intracellular …

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) may cause
sudden cardiac death (SCD) despite medical therapy. Therefore, implantable cardioverter …

BACKGROUND: In severely affected patients with catecholaminergic polymorphic
ventricular tachycardia, beta-blockers are often insufficiently protective. The purpose of this …

Sudden death is a rare event in the pediatric population but with a social shock due to its
presentation as the first symptom in previously healthy children. Comprehensive autopsy in …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare and potentially
lethal inherited arrhythmia disease characterized by exercise or emotion-induced …

Over the last three decades, the genetic basis of various inherited arrhythmia syndromes
has been elucidated, providing key insights into cardiomyocyte biology and various …

Background and Objectives Catecholaminergic polymorphic ventricular tachycardia (CPVT)
is a life-threatening inherited arrhythmogenic disorder. Recently, RYR2, the major CPVT …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare malignant inherited
arrhythmia syndrome, characterized by bidirectional or polymorphic ventricular arrhythmia …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe hereditary
arrhythmia syndrome predominantly affecting children and young adults. It manifests …