Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-
producing β cells. The mechanisms governing replication of terminally differentiated β cells …

Epigenetic modifications are crucial for proper lineage specification and embryo
development. To explore the chromatin modification landscapes in human ES cells, we …

Hox genes encode homeodomain-containing transcription factors that pattern the body axes
of animal embryos. It is well established that the exquisite DNA-binding specificity that …

Diabetes is a global epidemic problem growing exponentially in Asian countries posing a
serious threat. Among diabetes, maturity-onset diabetes of the young (MODY) is a …

Dysfunction of the exocrine pancreas is observed in diabetes, but links between concurrent
exocrine and endocrine pancreatic disease and contributing genetic factors are poorly …

Menin, the product of the Men1 gene mutated in familial multiple endocrine neoplasia type 1
(MEN1), regulates transcription in differentiated cells. Menin associates with and modulates …

The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and
decreased β-cell numbers, raising hope for cell replacement therapy. Although human islet …