Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize
arachidonic acid to substances which affect arterial tone, it has become increasingly clear …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

The myogenic response of small arteries and arterioles has been shown to contribute
significantly to autoregulation in different vascular beds. It is characterized by a constriction …

Mechanical forces generated at the endothelium by fluid shear stress and pulsatile stretch
are important in ensuring the continuous release of vasoactive endothelial autacoids …

Autoregulation of renal blood flow (RBF) is caused by the myogenic response (MR),
tubuloglomerular feedback (TGF), and a third regulatory mechanism that is independent of …

The kidney displays highly efficient autoregulation so that under steady-state conditions
renal blood flow (RBF) is independent of blood pressure over a wide range of pressure …

Animal and human studies support an untoward effect of excess dietary NaCl (salt) intake on
cardiovascular and renal function and life span. Recent work has promoted the concept that …

The intermediate filament vimentin might play a key role in vascular resistance to
mechanical stress. We investigated the responses to pressure (tensile stress) and flow …

The diagnosis of hypertensive nephrosclerosis is dependent on the exclusion of other
primary renal diseases. A careful past history, family history, search for signs for target organ …