Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Abstract Alzheimer's disease (AD), also called senile dementia, is the most common
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …

The continued drug discovery failures in complex neurodegenerative diseases, including
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …

The structural polymorphism and the physiological and pathophysiological roles of two
important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer's disease (AD) …

Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

Alzheimer's disease (AD) is a multifactorial disease characterized by the presence of
amyloid plaques, neurofibrillary tangles, and nerve cell death that affects, mainly, older …

Astrocytes, through their numerous processes, establish a bidirectional communication with
neurons that is crucial to regulate synaptic plasticity, the purported neurophysiological basis …

We introduce a novel audio processing architecture, the Open Voice Brain Model (OVBM),
improving detection accuracy for Alzheimer's (AD) longitudinal discrimination from …

Alzheimer's disease (AD) is the most common dementia affecting one in nine people over
65. Only a handful of small-molecule drugs and the anti-β amyloid (Aβ) antibody …