Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

In the decade since their discovery, the PH domain leucine-rich repeat protein
phosphatases (PHLPP) have emerged as critical regulators of cellular homeostasis, and …

Epigenetics, the inheritance of genomic information independent of DNA sequence, controls
the interpretation of extracellular and intracellular signals in cell homeostasis, proliferation …

The PI3K‐Akt pathway is one of the most commonly dysregulated cancer‐associated
signaling pathways. Here we report an oncogenic function for the miR‐181 family in luminal …

Protein kinase signalling, which transduces external messages to mediate cellular growth
and metabolism, is frequently deregulated in human disease, and specifically in cancer. As …

Highlights•PHLPP1 signalling is involved in diabetes mellitus and cardiovascular
diseases.•PHLPP1/2 deficiency is cardio-protective and athero-protective.•PHLPPs …

Whereas protein kinases have been successfully targeted for a variety of diseases, protein
phosphatases remain an underutilized therapeutic target, in part because of incomplete …

Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were
originally identified as protein kinase B (Akt) kinase hydrophobic motif specific …

Inflammation is an essential aspect of innate immunity but also contributes to diverse human
diseases. Although much is known about the kinases that control inflammatory signaling …

Chromatin structure and dynamics are highly controlled and regulated processes that play
an essential role in many aspects of cell biology. The chromatin transition stages and the …