Mechanism and regulation of kinesin motors
A Yildiz - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
EJ Wojcik, RS Buckley, J Richard, L Liu, TM Huckaba… - Gene, 2013 - Elsevier
Kinesin motor proteins comprise an ATPase superfamily that works hand in hand with
microtubules in every eukaryote. The mitotic kinesins, by virtue of their potential therapeutic …
microtubules in every eukaryote. The mitotic kinesins, by virtue of their potential therapeutic …
Directional switching of the kinesin Cin8 through motor coupling
Kinesin motor proteins are thought to move exclusively in either one or the other direction
along microtubules. Proteins of the kinesin-5 family are tetrameric microtubule cross-linking …
along microtubules. Proteins of the kinesin-5 family are tetrameric microtubule cross-linking …
Noncanonical interaction with microtubules via the N-terminal nonmotor domain is critical for the functions of a bidirectional kinesin
Several kinesin-5 motors (kinesin-5s) exhibit bidirectional motility. The mechanism of such
motility remains unknown. Bidirectional kinesin-5s share a long N-terminal nonmotor …
motility remains unknown. Bidirectional kinesin-5s share a long N-terminal nonmotor …
The structural basis of force generation by the mitotic motor kinesin-5
A Goulet, WM Behnke-Parks, CV Sindelar… - Journal of Biological …, 2012 - ASBMB
Kinesin-5 is required for forming the bipolar spindle during mitosis. Its motor domain, which
contains nucleotide and microtubule binding sites and mechanical elements to generate …
contains nucleotide and microtubule binding sites and mechanical elements to generate …
Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions.
Their motor domain drives these activities, but the molecular adaptations that specify these …
Their motor domain drives these activities, but the molecular adaptations that specify these …
Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition
Plasmodium parasites cause malaria and are responsible annually for hundreds of
thousands of deaths. Kinesins are a superfamily of microtubule-dependent ATPases that …
thousands of deaths. Kinesins are a superfamily of microtubule-dependent ATPases that …
Eg5 inhibitors have contrasting effects on microtubule stability and metaphase spindle integrity
To uncover their contrasting mechanisms, antimitotic drugs that inhibit Eg5 (kinesin-5) were
analyzed in mixed-motor gliding assays of kinesin-1 and Eg5 motors in which Eg5 “braking” …
analyzed in mixed-motor gliding assays of kinesin-1 and Eg5 motors in which Eg5 “braking” …
The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5
Kinesins perform mechanical work to power a variety of cellular functions, from mitosis to
organelle transport. Distinct functions shape distinct enzymologies, and this is illustrated by …
organelle transport. Distinct functions shape distinct enzymologies, and this is illustrated by …
Mechanisms by which kinesin-5 motors perform their multiple intracellular functions
H Pandey, M Popov, A Goldstein-Levitin… - International Journal of …, 2021 - mdpi.com
Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during
mitotic cell division. Their specialized structural characteristics enable these motors to …
mitotic cell division. Their specialized structural characteristics enable these motors to …