The main group of enzymes responsible for the collagen and other protein degradation in
extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main …

Enzymes underpin physiological function and exhibit dysregulation in many disease-
associated microenvironments and aberrant cell processes. Exploiting altered enzyme …

This review discusses the pathophysiology, epidemiology, risk factors, classification, clinical
evaluation, and current non-operative and operative treatment of hemorrhoids. Hemorrhoids …

In most cases, metastasis, not the primary tumour per se, is the main cause of mortality in
cancer patients. In order to effectively escape the tumour, enter the circulation and establish …

Angiogenesis is essential for tumor growth, metastasis, arteriosclerosis as well as embryonic
development and wound healing. Its process is dependent on cell proliferation, migration …

The past few decades have seen great progress in the exploration of nanoparticles (NPs) as
novel tools for cancer treatments and diagnosis. Practical and reliable application of …

Development and homeostasis of the cardiovascular system require intimate interactions
between endothelial and smooth muscle cells, which form a seamless circulatory network …

Colorectal cancer (CRC) represents the third type of cancer in incidence and second in
mortality worldwide, with the newly diagnosed case number on the rise. Among the …

Background: Raf kinase inhibitor protein (RKIP), an inhibitor of Raf-mediated activation of
mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK), is expressed …

Objective: To review the biological mechanisms and clinical utility of therapeutic modulation
of the host response in the management of periodontal diseases. Material and methods: A …