NRF2 in cardiovascular diseases: a ray of hope!

R Vashi, BM Patel - Journal of cardiovascular translational research, 2021 - Springer
Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is
expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function …

Artemisinin attenuates type 2 diabetic cardiomyopathy in rats through modulation of AGE-RAGE/HMGB-1 signaling pathway

EAE Farrag, MO Hammad, SM Safwat, S Hamed… - Scientific Reports, 2023 - nature.com
Diabetes mellitus is a common metabolic disorder. About two-thirds of diabetic patients
develop diabetic cardiomyopathy (DCM), which becomes a challenging issue as it severely …

Sodium butyrate controls cardiac hypertrophy in experimental models of rats

BM Patel - Cardiovascular toxicology, 2018 - Springer
The aim of the present research was to study the effect of sodium butyrate (SB) on partial
abdominal aorta constriction (PAAC)-induced cardiac hypertrophy and determine its …

Cardiac complications: the understudied aspect of cancer cachexia

V Bora, B Patel - Cardiovascular Toxicology, 2022 - Springer
The global burden of cancer cachexia is increasing along with drastic increase in cancer
patients. Cancer itself leads to cachexia, and cachexia development is associated with …

Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition

MM Patel, BM Patel - European Journal of Pharmaceutical Sciences, 2018 - Elsevier
Background and purpose Diabetic patients are at greater risk for colon cancer. Histone
deacetylases (HDACs) serve as common target for both. The key objective of the study was …

Beneficial role of telmisartan on cardiovascular complications associated with STZ-induced type 2 diabetes in rats

BR Goyal, K Parmar, RK Goyal, AA Mehta - Pharmacological Reports, 2011 - Springer
We studied the effect of an eight-week treatment with telmisartan (5 mg kg− 1 day− 1) on
cardiovascular complications that are associated with type 2 diabetes in a neonatal rat …

An evaluation of the protective role of Ficus racemosa Linn. in streptozotocin-induced diabetic neuropathy with neurodegeneration

ND Solanki, SK Bhavsar - Indian journal of pharmacology, 2015 - journals.lww.com
Objective: Ficus racemosa (FR) is one of the herbs mentioned in the scriptures of the
Ayurveda as Udumbara with high medicinal value. The objective of this study was to …

Secoisolariciresinol diglucoside rich extract of L. usitatissimum prevents diabetic colon cancer through inhibition of CDK4

NR Shah, BM Patel - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Background There is increased risk of colon cancer in both men and women having
diabetes. The objective of the study was to evaluate the role of Secoisolariciresinol …

Selective inhibition of HDAC2 by magnesium valproate attenuates cardiac hypertrophy

S Raghunathan, RK Goyal… - Canadian Journal of …, 2017 - cdnsciencepub.com
The regulatory paradigm in cardiac hypertrophy involves alterations in gene expression that
is mediated by chromatin remodeling. Various data suggest that class I and class II histone …

Aldosterone antagonists in monotherapy are protective against streptozotocin-induced diabetic nephropathy in rats

NF Banki, A Ver, LJ Wagner, A Vannay, P Degrell… - PLoS …, 2012 - journals.plos.org
Angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB)
are the standard clinical therapy of diabetic nephropathy (DN), while aldosterone …