Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches

M Sekhoacha, K Riet, P Motloung, L Gumenku… - Molecules, 2022 - mdpi.com
Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to
higher rates of mortality in those belonging to a lower socioeconomic status due to late …

[HTML][HTML] Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

D Ajmeera, R Ajumeera - Genes & Diseases, 2024 - Elsevier
Chemotherapy is an effortless and frequently used approach in cancer therapy. However, in
most cases, it can only prolong life expectancy and does not guarantee a complete cure …

[HTML][HTML] Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness …

M Rudrapal, N Gogoi, D Chetia, J Khan… - Saudi journal of …, 2022 - Elsevier
In view of the potential of traditional plant-based remedies (or phytomedicines) in the
management of COVID-19, the present investigation was aimed at finding novel anti-SARS …

Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors

S Rampogu, TS Jung, MW Ha, KW Lee - Scientific Reports, 2023 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a recent pandemic that caused serious
global emergency. To identify new and effective therapeutics, we employed a drug …

Computational methods directed towards drug repurposing for COVID-19: advantages and limitations

PP Sharma, M Bansal, A Sethi, L Pena, VK Goel… - RSC …, 2021 - pubs.rsc.org
Novel coronavirus disease 2019 (COVID-19) has significantly altered the socio-economic
status of countries. Although vaccines are now available against the severe acute …

The quest for secondary pharmaceuticals: drug repurposing/chiral-switches combination strategy

I D'Acquarica, I Agranat - ACS Pharmacology & Translational …, 2023 - ACS Publications
Drug repurposing toward new medical uses and chiral switches are elements of secondary
pharmaceuticals. The drug repurposing and chiral-switches strategies have mostly been …

Therapeutic targeting of repurposed anticancer drugs in Alzheimer's disease: Using the multiomics approach

D Advani, P Kumar - ACS omega, 2021 - ACS Publications
Aim/Hypothesis: The complexity and heterogeneity of multiple pathological features make
Alzheimer's disease (AD) a major culprit to global health. Drug repurposing is an …

Repurposing niclosamide for targeting pancreatic cancer by inhibiting hh/gli non-canonical axis of gsk3β

JB Kaushal, R Bhatia, RK Kanchan, P Raut… - Cancers, 2021 - mdpi.com
Simple Summary The current obstacles for discovering new drugs for cancer therapy have
necessitated the development of the alternative strategy of drug repurposing, the …

CREAMMIST: an integrative probabilistic database for cancer drug response prediction

H Yingtaweesittikul, J Wu, A Mongia… - Nucleic Acids …, 2023 - academic.oup.com
Extensive in vitro cancer drug screening datasets have enabled scientists to identify
biomarkers and develop machine learning models for predicting drug sensitivity. While most …

Identifying hub genes associated with neoadjuvant chemotherapy resistance in breast cancer and potential drug repurposing for the development of precision …

T Saha Detroja, R Detroja, S Mukherjee… - International Journal of …, 2022 - mdpi.com
Breast cancer is the second leading cause of morbidity and mortality in women worldwide.
Despite advancements in the clinical application of neoadjuvant chemotherapy (NAC), drug …