Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death.
The immune-rich contexture of the HCC microenvironment makes this tumour an appealing …

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …

肝癌是病死率最高的恶性肿瘤之一. 我国每年约有38.3 万人死于肝癌, 占全球肝癌死亡病例数的
51%, 严峻的形势给我国的社会和医疗带来了沉重的负担. 不断增加的科研经费投入为我国肝癌 …

Natural killer (NK) cells are enriched in lymphocytes within the liver and have unique
phenotypic features and functional properties, including tumor necrosis factor–related …

Exhaustion of cytotoxic effector natural killer (NK) and CD8+ T cells have important functions
in the establishment of persistent viral infections, but how exhaustion is induced during …

The liver has unique immune regulatory functions that promote the induction of tolerance
rather than responses to antigens encountered locally. These functions are mediated by …

The mechanisms linking hepatitis B virus (HBV) and hepatitis C virus (HCV) infection to
hepatocellular carcinoma (HCC) remain largely unknown. Natural killer (NK) cells account …

Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer mortality and
a common poor-prognosis malignancy due to postoperative recurrence and metastasis …

The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key
role in host defense against viral infection and tumor transformation. Recent evidence from …

Background. Natural killer (NK) cells are an integral part of the innate immune system. They
have been suggested to play an important role in both defense against viral hepatitis and …