Small RNAs, large networks: posttranscriptional regulons in gram-negative bacteria

K Papenfort, S Melamed - Annual review of microbiology, 2023 - annualreviews.org
Small regulatory RNA (sRNAs) are key mediators of posttranscriptional gene control in
bacteria. Assisted by RNA-binding proteins, a single sRNA often modulates the expression …

Two for one: Regulatory RNAs that encode small proteins

JJ Aoyama, G Storz - Trends in Biochemical Sciences, 2023 - cell.com
RNAs are commonly categorized as being either protein-coding mRNAs or noncoding
RNAs. However, an increasing number of transcripts, in organisms ranging from bacteria to …

Dual-function Spot 42 RNA encodes a 15–amino acid protein that regulates the CRP transcription factor

JJ Aoyama, M Raina, A Zhong… - Proceedings of the …, 2022 - National Acad Sciences
The 109-nucleotide Spot 42 RNA whose transcription is repressed by the cyclic adenosine
monophosphate receptor protein (CRP) is one of the best-characterized base-pairing small …

Recent insights into the world of dual‐function bacterial sRNAs

SB Schnoor, P Neubauer… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Dual‐function sRNAs refer to a small subgroup of small regulatory RNAs that merges base‐
pairing properties of antisense RNAs with peptide‐encoding properties of mRNA. Both …

[HTML][HTML] The power of the small: the underestimated role of small proteins in bacterial and archaeal physiology

B Jordan, K Weidenbach, RA Schmitz - Current Opinion in Microbiology, 2023 - Elsevier
Highlights•Small proteins are important players in multiple cellular processes.•Ribo-Seq
studies have improved the genome-wide identification of small proteins.•New strategies in …

Microproteins—Discovery, structure, and function

JJ Mohsen, AA Martel, SA Slavoff - Proteomics, 2023 - Wiley Online Library
Advances in proteogenomic technologies have revealed hundreds to thousands of
translated small open reading frames (sORFs) that encode microproteins in genomes across …

Ribosome profiling reveals the fine-tuned response of Escherichia coli to mild and severe acid stress

K Schumacher, R Gelhausen, W Kion-Crosby… - Msystems, 2023 - Am Soc Microbiol
The ability to respond to acidic environments is crucial for neutralophilic bacteria.
Escherichia coli has a well-characterized regulatory network that triggers a multitude of …

Large Roles of Small Proteins

AT Burton, R Zeinert, G Storz - Annual Review of Microbiology, 2024 - annualreviews.org
Bacterial proteins of≤ 50 amino acids, denoted small proteins or microproteins, have been
traditionally understudied and overlooked, as standard computational, biochemical, and …

Glutamine synthetase mRNA releases sRNA from its 3′ UTR to regulate carbon/nitrogen metabolic balance in Enterobacteriaceae

M Miyakoshi, T Morita, A Kobayashi, A Berger… - Elife, 2022 - elifesciences.org
Glutamine synthetase (GS) is the key enzyme of nitrogen assimilation induced under
nitrogen limiting conditions. The carbon skeleton of glutamate and glutamine, 2 …

FinO/ProQ-family proteins: an evolutionary perspective

Z Liao, A Smirnov - Bioscience reports, 2023 - portlandpress.com
RNA-binding proteins are key actors of post-transcriptional networks. Almost exclusively
studied in the light of their interactions with RNA ligands and the associated functional …