Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Enzymes fold into unique three-dimensional structures to distribute their reactive amino acid
residues, but environmental changes can disrupt their essential folding and lead to …

Histidine, a versatile proteinogenic amino acid, plays a broad range of roles in all living
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …

One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

During the billions of years of the evolutionary journey, primitive polymers, involved in proto
metabolic pathways with low catalytic activity, played critical roles in the emergence of …

Self-assembly of molecules often results in new emerging properties. Even very short
peptides can self-assemble into structures with a variety of physical and structural …

The reversible regulation of catalytic activity is a feature found in natural enzymes which is
not commonly observed in artificial catalytic systems. Here, we fabricate an artificial …

Enzymes play vital roles in cellular functions by catalyzing biochemical reactions in high
activity and selectivity, which is largely attributed to the cooperation between the exquisitely …

Peptides and their conjugates (to lipids, bulky N-terminals, or other groups) can self-
assemble into nanostructures such as fibrils, nanotubes, coiled coil bundles, and micelles …