Mechanisms of DNA damage, repair, and mutagenesis
N Chatterjee, GC Walker - Environmental and molecular …, 2017 - Wiley Online Library
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
Bacterial DNA excision repair pathways
KJ Wozniak, LA Simmons - Nature Reviews Microbiology, 2022 - nature.com
Bacteria are continuously exposed to numerous endogenous and exogenous DNA-
damaging agents. To maintain genome integrity and ensure cell survival, bacteria have …
damaging agents. To maintain genome integrity and ensure cell survival, bacteria have …
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools
AE Pegg - Chemical research in toxicology, 2011 - ACS Publications
O 6-Alkylguanine-DNA alkyltransferase (AGT) is a widely distributed, unique DNA repair
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …
DNA repair by reversal of DNA damage
Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic
and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms …
and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms …
Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems
R Morita, S Nakane, A Shimada, M Inoue… - Journal of nucleic …, 2010 - Wiley Online Library
DNA is subjected to many endogenous and exogenous damages. All organisms have
developed a complex network of DNA repair mechanisms. A variety of different DNA repair …
developed a complex network of DNA repair mechanisms. A variety of different DNA repair …
Flipping of alkylated DNA damage bridges base and nucleotide excision repair
JL Tubbs, V Latypov, S Kanugula, A Butt, M Melikishvili… - Nature, 2009 - nature.com
Alkyltransferase-like proteins (ATLs) share functional motifs with the cancer chemotherapy
target O 6-alkylguanine-DNA alkyltransferase (AGT) and paradoxically protect cells from the …
target O 6-alkylguanine-DNA alkyltransferase (AGT) and paradoxically protect cells from the …
[HTML][HTML] Atl1 regulates choice between global genome and transcription-coupled repair of O6-alkylguanines
VF Latypov, JL Tubbs, AJ Watson, AS Marriott… - Molecular cell, 2012 - cell.com
Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by
chemical carcinogens, and the molecular mechanism has been partially elucidated. Here …
chemical carcinogens, and the molecular mechanism has been partially elucidated. Here …
[HTML][HTML] Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3, N4-ethenocytosine-containing DNA
Reactive oxygen and nitrogen species, generated by neutrophils and macrophages in
chronically inflamed tissues, readily damage DNA, producing a variety of potentially …
chronically inflamed tissues, readily damage DNA, producing a variety of potentially …
Understanding the importance of low‐molecular weight (ethylene oxide‐and propylene oxide‐induced) DNA adducts and mutations in risk assessment: Insights from …
The interpretation and significance of DNA adduct data, their causal relationship to
mutations, and their role in risk assessment have been debated for many years. An …
mutations, and their role in risk assessment have been debated for many years. An …
Biochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants
R Miggiano, V Casazza, S Garavaglia… - Journal of …, 2013 - Am Soc Microbiol
Mycobacterium tuberculosis displays remarkable genetic stability despite continuous
exposure to the hostile environment represented by the host's infected macrophages …
exposure to the hostile environment represented by the host's infected macrophages …