AMPK is a highly conserved master regulator of metabolism, which restores energy balance
during metabolic stress both at the cellular and physiological levels. The identification of …

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Cellular energy is primarily provided by the oxidative degradation of nutrients coupled with
mitochondrial respiration, in which oxygen participates in the mitochondrial electron …

In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

The hydrolysis of ATP drives virtually all of the energy-requiring processes in living cells. A
prerequisite of living cells is that the concentration of ATP needs to be maintained at …

Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

The AMP-activated protein kinase (AMPK) was initially identified as the kinase that
phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting …

As a physiological small molecular product from the microbial fermentation of dietary fibers,
butyrate plays an important role in maintaining intestinal health. Our previous works have …

Germ line mutations in the LKB1 tumor suppressor gene are associated with the Peutz–
Jeghers polyposis and cancer syndrome. Somatic mutations in Lkb1 are observed in …

Research on the LKB1 tumor suppressor protein mutated in cancer-prone Peutz-Jeghers
patients has continued at a feverish pace following exciting developments linking energy …