In eons of evolution, isocyanides carved out a niche in the ecological systems probably
thanks to their metal coordinating properties. In 1859 the first isocyanide was synthesized by …

Covering: 2004. Previous review: Nat. Prod. Rep., 2005, 22, 15This review covers the
literature published in 2004 for marine natural products, with 693 citations (491 for the …

Sea sponges are the largest marine source of small-molecule natural products described to
date. Sponge-derived molecules, such as the chemotherapeutic eribulin, the calcium …

The marine environment is distinguished by unique groups of organisms being the source of
a wide array of fascinating structures. The enormous biodiversity of marine habitats is …

The structure elucidation, biosynthesis, and biological activity of marine carbotricyclic
sesquiterpene compounds are reviewed from the pioneering results to the end of 2015 …

Marine natural products play critical roles in the chemical defense of many marine
organisms and in some cases can influence the community structure of entire ecosystems …

The SN2 reaction (bimolecular nucleophilic substitution) is a well-known chemical
transformation that can be used to join two smaller molecules together into a larger molecule …

Marine invertebrates provide a rich source of metabolites with anticancer activities and
several marine-derived agents have been approved for the treatment of cancer. However …

Diterpenoid alkaloids are natural compounds having complex structural features with many
stereo-centres originating from the amination of natural tetracyclic diterpenes and produced …

We show here that isonitriles can perform click reactions with tetrazines in aqueous media,
making them promising candidates for ligation reactions in chemical biology and polymer …