[HTML][HTML] Sulforaphane and its bifunctional analogs: Synthesis and biological activity

Ł Janczewski - Molecules, 2022 - mdpi.com
For decades, various plants have been studied as sources of biologically active compounds.
Compounds with anticancer and antimicrobial properties are the most frequently desired …

Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis

X Dong, X Yu, M Lu, Y Xu, L Zhou, T Peng - Cell Death Discovery, 2024 - nature.com
Naturally occurring isothiocyanates (ITCs) found in cruciferous vegetables, such as benzyl
isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and sulforaphane (SFN), have …

Bifunctional non-canonical amino acids: combining photo-crosslinking with click chemistry

JE Hoffmann - Biomolecules, 2020 - mdpi.com
Genetic code expansion is a powerful tool for the study of protein interactions, as it allows for
the site-specific incorporation of a photoreactive group via non-canonical amino acids …

Synthesis of Isothiocyanates Using DMT/NMM/TsO as a New Desulfurization Reagent

Ł Janczewski, D Kręgiel, B Kolesińska - Molecules, 2021 - mdpi.com
Thirty-three alkyl and aryl isothiocyanates, as well as isothiocyanate derivatives from esters
of coded amino acids and from esters of unnatural amino acids (6-aminocaproic, 4 …

Advances in molecular signaling mechanisms of β-phenethyl isothiocyanate antitumor effects

CZ Qin, X Zhang, LX Wu, CJ Wen, L Hu… - Journal of agricultural …, 2015 - ACS Publications
β-Phenethyl isothiocyanate (PEITC) is an important phytochemical from cruciferous
vegetables and is being evaluated for chemotherapeutic activity in early phase clinical trials …

Mannich reactions and the synthesis of heterocycles as antiproliferative agents in cancer and neglected tropical disease

JA Kavouris - 2020 - search.proquest.com
Efficient construction of CN bonds and nitrogen-containing heterocycles is instrumental in
synthesizing chemical building blocks with direct applicability to the pharmaceutical industry …

Synthesis of phosphino-triazole ligands

Y Zhao - 2020 - etheses.bham.ac.uk
The triazole formation via click chemistry has remained a hot topic in recent years. This
thesis disclosed the synthesis of triazole containing phosphine ligand for catalysts work …

Synthesis of aza-spirocyclic dienones and their application toward natural product synthesis and synthesis and evaluation of anticancer tetracyclic indole containing …

WL Montgomery - 2016 - repositories.lib.utexas.edu
A novel route to access the aza-spirocyclic cross-conjugated dienone motif was developed
utilizing an intramolecular phenolic C-alkylation and Suzuki coupling to form the key …