Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Recent progress in the electrochemical selenofunctionalization of alkenes and alkynes

P Qu, YQ Jiang, YH Wang, GQ Liu - Green Chemistry, 2023 - pubs.rsc.org
Organoselenium compounds, a significant class of substances with applications in the
biological, medicinal and material sciences as well as in modern organic synthesis, have …

Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)

D Tan, L Loots, T Friščić - Chemical Communications, 2016 - pubs.rsc.org
This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Laccase and laccase‐mediated systems in the synthesis of organic compounds

M Mogharabi, MA Faramarzi - Advanced Synthesis & Catalysis, 2014 - Wiley Online Library
Laccase, a blue multicopper oxidase, has recently received considerable attention because
of its usefulness in oxidizing phenolic and non‐phenolic compounds, as well as its suitability …

Mechanochemical preparation of hydantoins from amino esters: application to the synthesis of the antiepileptic drug phenytoin

L Konnert, B Reneaud, RM de Figueiredo… - The Journal of …, 2014 - ACS Publications
The eco-friendly preparation of 5-and 5, 5-disubstituted hydantoins from various amino ester
hydrochlorides and potassium cyanate in a planetary ball-mill is described. The one-pot/two …

Designing, DFT, biological, & molecular docking analysis of new Iron (III) & copper (II) complexes incorporating 1-{[-(2-Hydroxyphenyl) methylene] amino}− 5, 5 …

MM Khalaf, HM Abd El-Lateef, M Gouda… - … Biology and Chemistry, 2024 - Elsevier
The exploration encompassed the synthesis and characterization of two innovative
complexes, namely FePHNS and CuPHNS, employing a diverse array of analytical …

[HTML][HTML] One-pot three-component synthesis of novel phenyl-pyrano-thiazol-2-one derivatives and their anti-diabetic activity studies

S Prabhakaran, N Nivetha, SM Patil, RM Martiz… - Results in …, 2022 - Elsevier
An easy and rapid synthetic approach for the synthesis of phenyl-pyrano-thiazol-2-one
derivatives using base catalysed one-pot three-component reaction between substituted …

Molecular structure, spectroscopic, dielectric and thermal study, nonlinear optical properties, natural bond orbital, HOMO-LUMO and molecular docking analysis of …

S Hosna, DE Janzen, YS Mary, KS Resmi… - … Acta Part A: Molecular …, 2018 - Elsevier
A new chloranilate compound with 1-(2-fluorophenyl) piperazine has been synthesized and
characterized using spectroscopic methods and X-ray diffraction. The atomic arrangement …

Evaluation of sublimation enthalpy by thermogravimetry: Analysis of the diffusion effects in the case of methyl and phenyl substituted hydantoins

F Ramos, JM Ledo, H Flores, EA Camarillo… - Thermochimica …, 2017 - Elsevier
By using a thermogravimetric analyzer, and applying the Clausius-Clapeyron and Langmuir
equations, the enthalpies of sublimation and/or vaporization of a set of organic compounds …

Continuous synthesis of hydantoins: Intensifying the Bucherer–Bergs reaction

JL Monteiro, B Pieber, AG Corrêa, CO Kappe - Synlett, 2016 - thieme-connect.com
A continuous Bucherer–Bergs hydantoin synthesis utilizing intensified conditions is
reported. The methodology is characterized by a two-feed flow approach to independently …