Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …

Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a
frequent complication in cirrhosis that adversely affects clinical outcomes. These include …

Background Malnutrition/sarcopenia and frailty are common in patients with cirrhosis and
are associated with poor outcomes. Aim To provide an overview of data on the importance …

SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino
acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved …

SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …

Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated
mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as …

Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to
reach their final targets. The optimal targets of most cancer therapeutic agents are usually …

Autophagy is a catabolic process with an essential function in the maintenance of cellular
and tissue homeostasis. It is primarily recognised for its role in the degradation of …

The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that
regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a …