Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation
process in which they gradually acquire T-cell characteristics while shedding their legacy of …

All hematopoietic cells, including T lymphocytes, originate from stem cells that reside in the
bone marrow. Most hematopoietic lineages also mature in the bone marrow, but in this …

Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …

Genome-scale studies have revealed extensive, cell type-specific colocalization of
transcription factors, but the mechanisms underlying this phenomenon remain poorly …

Notch signalling is a central regulator of differentiation in a variety of organisms and tissue
types. Its activity is controlled by the multi-subunit γ-secretase (γSE) complex. Although …

The zinc-finger transcription factor GATA-3 has received much attention as a master
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …

Recent studies have shown that activating mutations of NOTCH1 are responsible for the
majority of T cell acute lymphoblastic leukemia (T-ALL) cases. Most of these mutations …

Natural killer (NK) cell development is thought to occur in the bone marrow. Here we identify
the transcription factor GATA-3 and CD127 (IL-7Rα) as molecular markers of a pathway of …

NK cells sit at the crossroads of innate and adaptive immunity and help coordinate tumor
immunosurveillance and the immune response against pathogens. Balancing signals to NK …

Hematopoiesis is a process capable of generating millions of cells every second, as
distributed in many cell types. The process is regulated by a number of transcription factors …