Peptides as multifunctional players in cancer therapy

SMP Vadevoo, S Gurung, HS Lee… - … & Molecular Medicine, 2023 - nature.com
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

[HTML][HTML] Recent preclinical and clinical progress in liposomal doxorubicin

K Aloss, P Hamar - Pharmaceutics, 2023 - mdpi.com
Doxorubicin (DOX) is a potent anti-cancer agent that has garnered great interest in research
due to its high efficacy despite dose-limiting toxicities. Several strategies have been …

Peptide-based agents for cancer treatment: current applications and future directions

NTT Nhàn, T Yamada, KH Yamada - International Journal of Molecular …, 2023 - mdpi.com
Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

PEG-grafted arsenic trioxide-loaded mesoporous silica nanoparticles endowed with pH-triggered delivery for liver cancer therapy

L Jiang, X Wang, F Raza, H Zhong, J Su… - Biomaterials …, 2023 - pubs.rsc.org
Liver cancer (LC), one of the most common malignant primary tumors, presents a poor
prognosis, high morbidity rate, and poor clinical outcomes. Despite conventional treatments …

Delivery of theranostic nanoparticles to various cancers by means of integrin-binding peptides

EA Egorova, MP Nikitin - International Journal of Molecular Sciences, 2022 - mdpi.com
Active targeting of tumors is believed to be the key to efficient cancer therapy and accurate,
early-stage diagnostics. Active targeting implies minimized off-targeting and associated …

Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes

N Kato, S Yamada, R Suzuki, Y Iida, M Matsumoto… - Drug Delivery, 2023 - Taylor & Francis
Liposomes are versatile carriers that can encapsulate various drugs; however, for delivery to
the brain, they must be modified with a targeting ligand or other modifications to provide …

A PEGylated nanostructured lipid carrier for enhanced oral delivery of antibiotics

SE Alavi, U Bakht, M Koohi Moftakhari Esfahani… - Pharmaceutics, 2022 - mdpi.com
Antimicrobial resistance is a major concern for public health throughout the world that
severely restricts available treatments. In this context, methicillin-resistant Staphylococcus …

RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions

H Javid, MA Oryani, N Rezagholinejad… - Cancer …, 2024 - Wiley Online Library
RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin,
vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by …

Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives

Y Sugimoto, T Suga, M Umino, A Yamayoshi… - Drug Delivery, 2023 - Taylor & Francis
Functionalized drug delivery systems have been investigated to improve the targetability
and intracellular translocation of therapeutic drugs. We developed high functionality and …

Influence of lipid composition of messenger RNA-loaded lipid nanoparticles on the protein expression via intratracheal administration in mice

L Geng, N Kato, Y Kodama, H Mukai… - International Journal of …, 2023 - Elsevier
Intratracheal (it) administration, which takes advantage of the specific structure of the
respiratory system, can effectively deliver nanoparticles to the lung. Much remains unknown …