Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Presence of the human cytomegalovirus in glioblastomas—A systematic review

I Peredo-Harvey, A Rahbar, C Söderberg-Nauclér - Cancers, 2021 - mdpi.com
Simple Summary Whether the human cytomegalovirus (HCMV) is present in samples
obtained from patients with glioblastoma (GBM) has been a matter under debate during the …

The epidemiology of central nervous system tumors

SS Francis, QT Ostrom, DJ Cote… - Hematology …, 2022 - hemonc.theclinics.com
Understanding of the epidemiology of central nervous system (CNS) tumors has grown
substantially in the past 2 decades. Surveillance systems in the United States and …

Cytomegalovirus and glioblastoma: a review of the biological associations and therapeutic strategies

T Yang, D Liu, S Fang, W Ma, Y Wang - Journal of clinical medicine, 2022 - mdpi.com
Glioblastoma is the most common and aggressive malignancy in the adult central nervous
system. Cytomegalovirus (CMV) plays a crucial role in the pathogenesis and treatment of …

Valganciclovir as add-on to second-line therapy in patients with recurrent glioblastoma

MR Pantalone, A Rahbar, C Söderberg-Naucler… - Cancers, 2022 - mdpi.com
Simple Summary Patients with glioblastoma have a dismal prognosis. The major challenge
with this disease is that it recurs despite aggressive first-line therapy and rapidly becomes …

Repositioning Lopinavir, an HIV Protease Inhibitor, as a Promising Antifungal Drug: Lessons Learned from Candida albicans—In Silico, In Vitro and In Vivo …

ALS Santos, LA Braga-Silva, DS Gonçalves, LS Ramos… - Journal of Fungi, 2021 - mdpi.com
The repurposing strategy was applied herein to evaluate the effects of lopinavir, an aspartic
protease inhibitor currently used in the treatment of HIV-infected individuals, on the globally …

Human cytomegalovirus infection enhances 5‑lipoxygenase and cycloxygenase‑2 expression in colorectal cancer

MR Pantalone, N Martin Almazan… - International …, 2023 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most common and fatal types of cancer. Inflammation
promotes CRC development, however, the underlying etiological factors are unknown …

Recent advances in the detection of glioblastoma, from imaging-based methods to proteomics and biosensors: A narrative review

A Hosseini, H Ashraf, F Rahimi, I Alipourfard… - Cancer Cell …, 2023 - Springer
Glioblastoma (GBM) is an aggressive type of cancer that originates in the cells called
astrocytes, which support the functioning of nerve cells. It can develop in either the brain or …

Human Cytomegalovirus Protein Expression Is Correlated with Shorter Overall Survival in Breast Cancer Patients: A Cohort Study

J Touma, MR Pantalone, A Rahbar, Y Liu, K Vetvik… - Viruses, 2023 - mdpi.com
Background: Human cytomegalovirus (HCMV) is increasingly suggested to be involved in
human carcinogenesis and onco-modulation due to its ability to contribute to all hallmarks of …

Metabolic reprogramming of glioblastoma cells during HCMV infection induces secretome-mediated paracrine effects in the microenvironment

MAA Harrison, EM Hochreiner, BP Benjamin… - Viruses, 2022 - mdpi.com
Glioblastoma (GBM) is an aggressive primary central nervous system neoplasia with limited
therapeutic options and poor prognosis. Following reports of cytomegalovirus (HCMV) in …