Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …

Abstract Analysis of single-cell RNA-Seq data can provide insights into the specific functions
of individual cell types that compose complex tissues. Here, we examined gene expression …

Abstract Semaphorin-4A (Sema4A) has been implicated in the co-stimulation of T cells and
drives Th1 immune responses by binding to the receptor T-cell immunoglobulin and mucin …

The accessibility of cell surface proteins makes them tractable for targeting by cancer
immunotherapy, but identifying suitable targets remains challenging. Here we describe …

Semaphorins are a group of proteins that are divided into eight subclasses and identified by
a conserved Sema domain on their carboxyl terminus. Sema4A, 4C, and 4D are the …

The semaphorin family members were originally considered to play a role in
neurodevelopment, angiogenesis, tumor development, and metastasis. Over the past few …

To understand how proper circuit formation and function is established in the mammalian
brain, it is necessary to define the genes and signaling pathways that instruct excitatory and …

Long-term inflammatory processes directed at a particular endogenous or exogenous
antigen, or sometimes of unknown etiology, form the pathogenetic basis for many …

Neutrophil migration is an essential step in leukocyte trafficking during inflammatory
responses. Semaphorins, originally discovered as axon guidance cues in neural …