Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …

The prevalence of type 2 diabetes (T2D) is increasing relentlessly all over the world, in
parallel with a similar increase in obesity, and is striking ever younger patients. Only a …

Objective To evaluate the efficacy and safety of dorzagliatin in the treatment of type 2
diabetes mellitus (T2DM) by using meta-analysis and trial sequential analysis (TSA). Method …

Chronic hyperglycemia increases pancreatic β-cell metabolic activity, contributing to
glucotoxicity-induced β-cell failure and loss of functional β-cell mass, potentially in multiple …

Glucokinase activators are regarded as potent candidates for diabetes treatment, however,
in clinical studies on patients with type 2 diabetes, a diminishing efficacy was observed after …

The prevalence of diabetes is increasing worldwide. Massive death of pancreatic beta-cells
causes type 1 diabetes. Progressive loss of beta-cell function and mass characterizes type 2 …

Diabetes is a chronic, and metabolic disorder that has gained epidemic proportions in the
past few decades creating a threat throughout the globe. It is characterized by increased …

As a sensor, glucokinase (GK) controls glucose homeostasis, which progressively declines
in patients with diabetes. GK maintains the equilibrium of glucose levels and regulates the …

Introduction The number of diabetic patients is increasing, posing a heavy social and
economic burden worldwide. Traditional drug development technology is time-consuming …

The international diabetes research community has lost a giant with the passing of Franz
Matschinsky. Franz was a scientist's scientist, whose important discovery of glucokinase as …