Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage
Understanding the intricate mechanisms governing the cellular response to resistance
exercise is paramount for promoting healthy aging. This narrative review explored the age …
exercise is paramount for promoting healthy aging. This narrative review explored the age …
Elevated myonuclear density during skeletal muscle hypertrophy in response to training is reversed during detraining
Myonuclei gained during exercise-induced skeletal muscle hypertrophy may be long-lasting
and could facilitate future muscle adaptability after deconditioning, a concept colloquially …
and could facilitate future muscle adaptability after deconditioning, a concept colloquially …
Skeletal muscle aging atrophy: assessment and exercise-based treatment
GN Marzuca-Nassr, Y SanMartín-Calísto… - Reviews on New Drug …, 2020 - Springer
In the ordinary course of aging, individuals change their body composition, mainly reducing
their skeletal muscle mass and increasing their fat mass. In association, muscle strength and …
their skeletal muscle mass and increasing their fat mass. In association, muscle strength and …
Myofibrillar protein synthesis rates are increased in chronically exercised skeletal muscle despite decreased anabolic signaling
The molecular responses to acute resistance exercise are well characterized. However, how
cellular signals change over time to modulate chronic adaptations to more prolonged …
cellular signals change over time to modulate chronic adaptations to more prolonged …
Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations
KA Kobak, MM Lawrence, G Pharaoh… - Journal of cachexia …, 2021 - Wiley Online Library
Background Ageing and cachexia cause a loss of muscle mass over time, indicating that
protein breakdown exceeds protein synthesis. Deuterium oxide (D2O) is used for studies of …
protein breakdown exceeds protein synthesis. Deuterium oxide (D2O) is used for studies of …
Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy
Skeletal muscle mass is regulated through coordinated activation of multiple signaling
pathways. TAK1 signalosome has been found to be activated in various conditions of …
pathways. TAK1 signalosome has been found to be activated in various conditions of …
Low-load blood flow-restricted resistance exercise produces fiber type-independent hypertrophy and improves muscle functional capacity in older individuals
J Wang, AMG Mogensen, F Thybo… - Journal of Applied …, 2023 - journals.physiology.org
Low-load blood flow-restricted resistance exercise (BFRRE) constitutes an effective means
to produce skeletal muscle hypertrophy. Nonetheless, its applicability to counteract the age …
to produce skeletal muscle hypertrophy. Nonetheless, its applicability to counteract the age …
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
The tumor suppressor p53 is thought to play a key role in the maintenance of cell size and
homeostasis, but relatively little is known about its role in skeletal muscle. Based on its …
homeostasis, but relatively little is known about its role in skeletal muscle. Based on its …
Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis
K Ramachandran, CR Futtner, MA Sommars… - Nature …, 2024 - nature.com
Skeletal muscle is dynamically controlled by the balance of protein synthesis and
degradation. Here we discover an unexpected function for the transcriptional repressor B …
degradation. Here we discover an unexpected function for the transcriptional repressor B …
Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates
Perturbations in skeletal muscle metabolism have been reported for a variety of
neuromuscular diseases. However, the role of metabolism after constriction injury to a nerve …
neuromuscular diseases. However, the role of metabolism after constriction injury to a nerve …