After several decades, therapeutic cancer vaccines now show signs of efficacy and potential
to help patients resistant to other standard-of-care immunotherapies, but they have yet to …

Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

Neuropathic pain is often caused by injury and diseases that affect the somatosensory
system. Although pain development has been well studied, pain recovery mechanisms …

The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane
protein that is a target of therapeutics for infectious diseases and cancer. However, early …

Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …

Despite multiple immunotherapeutic technologies that achieve potent T cell activation,
effector T cells still lack efficiency because of the highly immunosuppressive conditions in …

Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage.
We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing …

Understanding of the factors governing immune responses in cancer remains incomplete,
limiting patient benefit. In this study, we used mass cytometry to define the systemic immune …

Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system,
and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory …