The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …

To ensure the high-fidelity transmission of genetic information, cells have evolved
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …

As its name suggests, the ATM?'ataxia-telangiectasia, mutated'? gene is responsible for the
rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their …

The process of homologous recombinational repair (HRR) is a major DNA repair pathway
that acts on double-strand breaks and interstrand crosslinks, and probably to a lesser extent …

Gene targeting in mammalian cells has proven invaluable in biotechnology, in studies of
gene structure and function, and in understanding chromosome dynamics. It also offers a …

One of the cornerstones of the web of signaling pathways governing cellular life and
differentiation is the DNA damage response. It spans a complex network of pathways …

There is increasing evidence for the involvement of repetitive DNA sequences as facilitators
of some of the recurrent chromosomal rearrangements observed in human tumors. The high …

The conserved Mre11 complex (Mre11, Rad50, and Nbs1) plays a role in each aspect of
chromosome break metabolism. The complex acts as a break sensor and functions in the …

Over 50% of all patients with cancer are treated with radiotherapy. However, radiotherapy is
often insufficient as a monotherapy and requires a nontoxic radiosensitizer. Squalene …

Ataxia telangiectasia (AT) is a hereditary human disorder resulting in a wide variety of
clinical manifestations, including progressive neurodegeneration, immunodeficiency, and …