Paraspinal muscle pathophysiology associated with low back pain and spine degenerative disorders

AM Noonan, SHM Brown - JOR spine, 2021 - Wiley Online Library
Low back pain disorders affect more than 80% of adults in their lifetime and are the leading
cause of global disability. The muscles attaching to the spine (ie, paraspinal muscles) are …

[HTML][HTML] Intervertebral disc degeneration and regeneration: a motion segment perspective

B Ashinsky, HE Smith, RL Mauck… - European cells & …, 2021 - ncbi.nlm.nih.gov
Back and neck pain have become a primary cause of disability and healthcare spending
globally. While the causes of back pain are multifactorial, intervertebral disc degeneration is …

Spatial transcriptomics tools allow for regional exploration of heterogeneous muscle pathology in the pre-clinical rabbit model of rotator cuff tear

S Ruoss, MC Esparza, LS Vasquez-Bolanos… - Journal of orthopaedic …, 2022 - Springer
Background Conditions affecting skeletal muscle, such as chronic rotator cuff tears, low back
pain, dystrophies, and many others, often share changes in muscle phenotype …

The relationship between the degeneration and asymmetry of the lumbar multifidus and erector spinae muscles in patients with lumbar disc herniation with and …

A Yazici, T Yerlikaya - Journal of Orthopaedic Surgery and Research, 2022 - Springer
Background The determination of muscle pathologies in lumbar disc herniation (LDH) and
other conditions with low back pain is important for understanding low back problems and …

Regional differences between superficial and deep lumbar multifidus in patients with chronic lumbar spine pathology

J Padwal, DB Berry, JC Hubbard, V Zlomislic… - BMC musculoskeletal …, 2020 - Springer
Background Due to its unique arrangement, the deep and superficial fibers of the multifidus
may have differential roles for maintaining spine stabilization and lumbar posture; the …

Characteristics of paraspinal muscle degeneration in degenerative diseases of the lumbar spine at different ages

D Sun, Z Wang, J Mou, F Tian, J Cao, L Guo… - Clinical Neurology and …, 2022 - Elsevier
Objective To analyze the relationship between gender, age, and the degree of lumbar
degenerative disease. Methods 290 patients with Lumbar spinal stenosis and sciatica were …

Paraspinal muscle morphology and composition in adolescent idiopathic scoliosis: A histological analysis

B Shahidi, A Yoo, C Farnsworth, PO Newton… - JOR …, 2021 - Wiley Online Library
Background Adolescent idiopathic scoliosis (AIS) is a condition resulting in spinal deformity
and tissue adaptation of the paraspinal muscles. Although prior studies have demonstrated …

Dysfunctional paraspinal muscles in adult spinal deformity patients lead to increased spinal loading

M Malakoutian, AM Noonan, I Dehghan-Hamani… - European Spine …, 2022 - Springer
Purpose Decreased spinal extensor muscle strength in adult spinal deformity (ASD) patients
is well-known but poorly understood; thus, this study aimed to investigate the biomechanical …

Paraspinal muscles in individuals undergoing surgery for lumbar spine pathology lack a myogenic response to an acute bout of resistance exercise

B Shahidi, B Anderson, A Ordaz, DB Berry… - JOR …, 2024 - Wiley Online Library
Background Lumbar spine pathology (LSP) is a common source of low back or leg pain, and
paraspinal muscle in these patients demonstrates fatty and fibrotic infiltration, and cellular …

Paraspinal muscle contractile function is impaired in the ENT1-deficient mouse model of progressive spine pathology

AM Noonan, CA Séguin, SHM Brown - Spine, 2021 - journals.lww.com
Study Design Basic science study of the relationship between spine pathology and the
contractile ability of the surrounding muscles. Objective The aim of this study was to …