Hypoxia is a hallmark of the tumour microenvironment with profound effects on tumour
biology, influencing cancer progression, the development of metastasis and patient …

Ionizing radiation (IR) is a form of high energy. It poses a serious threat to organisms, but
radiotherapy is a key therapeutic strategy for various cancers. It is significant to reduce …

Local hypoxia in solid tumors often results in resistance to radiotherapy (RT), in which
oxygen is an essential element for enhancing DNA damage caused by ionizing radiation …

PrimPol is a DNA damage tolerance enzyme possessing both translesion synthesis (TLS)
and primase activities. To uncover its potential role in TLS-mediated IgVλ hypermutation and …

The drug floxuridine (5-fluorodeoxyuridine, FUdR) is an active metabolite of 5-Fluorouracil
(5-FU). It converts to 5-fluorodeoxyuridine monophosphate (FdUMP) and 5 …

Benzo [a] pyrene and N-nitrosodimethylamine are major genotoxic compounds present in
cigarette smoke, food and oil. To examine the type (s) of DNA damage induced by these …

Prolonged replication arrest on damaged templates is a cause of fork collapse, potentially
resulting in genome instability. Arrested replication is rescued by translesion DNA synthesis …

Various types of DNA lesions are produced when cells are exposed to ionizing radiation
(IR). The type and yield of IR-induced DNA damage is influenced by the oxygen …

A nucleoside analog, Cidofovir (CDV), is used for the treatment of viral diseases such as
cytomegalovirus retinitis and herpes virus infection. CDV converts to its active diphosphate …

Alovudine is a chain-terminating nucleoside analog (CTNA) that is frequently used as an
antiviral and anticancer agent. Generally, CTNAs inhibit DNA replication after their …