Various environmental stressors, such as extreme temperatures (hot and cold), pathogens,
predators and insufficient food, can threaten life. Remarkable progress has recently been …

Sleep and body temperature are tightly interconnected in mammals: warming up our body
helps to fall asleep and the body temperature in turn drops while falling asleep. The preoptic …

During infection, animals exhibit adaptive changes in physiology and behaviour aimed at
increasing survival. Although many causes of infection exist, they trigger similar stereotyped …

Single-cell RNA-sequencing (scRNA-seq) is an indispensable tool for characterizing cellular
diversity and generating hypotheses throughout biology. Droplet-based scRNA-seq datasets …

The opsin family of G-protein-coupled receptors are used as light detectors in animals.
Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to …

Homeotherms maintain a stable internal body temperature despite changing environments.
During energy deficiency, some species can cease to defend their body temperature and …

For over a century, the role of the preoptic hypothalamus and adjacent basal forebrain in
sleep–wake regulation has been recognized. However, for years, the identity and location of …

The preoptic area (POA) is a key brain region for regulation of body temperature (Tb),
dictating thermogenic, cardiovascular, and behavioral responses that control Tb. Previously …

The preoptic area (POA) has long been recognized as a sleep center, first proposed by von
Economo. The POA, especially the medial POA (MPOA), is also involved in the regulation of …

The bidirectional controller of the thermoregulatory center in the preoptic area (POA) is
unknown. Using rats, here, we identify prostaglandin EP3 receptor–expressing POA …