The resurgence of tuberculosis worldwide has intensified research efforts directed at
examining the host defense and pathogenic mechanisms operative in Mycobacterium …

Mycobacteria are endowed with mechanisms through which they can evade the onslaught
of host defense response. These mechanisms are discussed including diminishing the …

Control of tuberculosis worldwide depends on our understanding of human immune
mechanisms, which combat the infection. Acquired T cell responses are critical for host …

The attenuated strain of Mycobacterium bovis bacille Calmette–Guérin (BCG) is the most
widely used vaccine in the world. In most children, inoculation of live BCG vaccine is …

We have examined the effect of killing of host monocytes infected with bacillus Calmette-
Guérin (BCG) on the viability of the intracellular mycobacteria. Peripheral blood monocytes …

Mycobacterium tuberculosis and Mycobacterium leprae, the causative agents of tuberculosis
and leprosy, respectively, produce large quantities of lipoarabinomannan (LAM), a highly …

Tuberculosis (TB) remains a serious global public health problem that results in up to 2
million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis …

Central to understanding the pathogenesis of tuberculosis is the interaction between the
pathogen and mononuclear phagocytes. A key question about that interaction is whether …

Mycobacterium avium (MAC) organisms multiply in phagosomes that have restricted
fusigenicity with lysosomes, do not acidify due to a paucity of vacuolar proton-ATPases, yet …

Mycobacterium tuberculosis is a very successful pathogen that can survive and persist in the
human host in the face of a robust immune response. This immune response is sufficient to …