Understanding the pathogenesis and clinical manifestations of systemic lupus
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …

Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenesis by …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies …

Systemic lupus erythematosus (SLE), a common lethal autoimmune disease, is
characterized by effector/regulatory T cells imbalance. Current therapies are either inefficient …

B cells have a prominent role in the pathogenesis of systemic lupus erythematosus (SLE).
They are mediators of inflammation through the production of pathogenic antibodies that …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibody (ANA) production. ANAs bind to DNA, RNA and complexes of proteins …

Aberrant B cell signaling plays a critical in role in various systemic and organ-specific
autoimmune diseases. This is supported by genetic evidence by many functional studies in …

The major therapeutic goal for immune thrombocytopenic purpura (ITP) is to restore normal
platelet counts using drugs to promote platelet production or by interfering with mechanisms …

Autoimmunity is the break of tolerance to self‐antigens that leads to organ‐specific or
systemic diseases often characterized by the presence of pathogenic autoreactive …