Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms
AF Khan, Y Iturria-Medina - Translational Psychiatry, 2024 - nature.com
From Alzheimer's disease to amyotrophic lateral sclerosis, the molecular cascades
underlying neurodegenerative disorders remain poorly understood. The clinical view of …
underlying neurodegenerative disorders remain poorly understood. The clinical view of …
Discovering a reaction–diffusion model for Alzheimer's disease by combining PINNs with symbolic regression
Misfolded tau proteins play a critical role in the progression and pathology of Alzheimer's
disease. Recent studies suggest that the spatio-temporal pattern of misfolded tau follows a …
disease. Recent studies suggest that the spatio-temporal pattern of misfolded tau follows a …
A multi-scale model explains oscillatory slowing and neuronal hyperactivity in Alzheimer's disease
CG Alexandersen, W de Haan… - Journal of the Royal …, 2023 - royalsocietypublishing.org
Alzheimer's disease is the most common cause of dementia and is linked to the spreading of
pathological amyloid-β and tau proteins throughout the brain. Recent studies have …
pathological amyloid-β and tau proteins throughout the brain. Recent studies have …
Uncertainty quantification for Fisher-Kolmogorov equation on graphs with application to patient-specific Alzheimer's disease
The Fisher-Kolmogorov equation is a diffusion-reaction PDE that models the accumulation
of prionic proteins, which are responsible for many different neurological disorders. The …
of prionic proteins, which are responsible for many different neurological disorders. The …
Front propagation and arrival times in networks with application to neurodegenerative diseases
Many physical, epidemiological, or physiological dynamical processes on networks support
front-like propagation, where an initial localized perturbation grows and systematically …
front-like propagation, where an initial localized perturbation grows and systematically …
Personalised regional modelling predicts tau progression in the human brain
Aggregation of the hyperphosphorylated tau protein is a central driver of Alzheimer's
disease, and its accumulation exhibits a rich spatio-temporal pattern that unfolds during the …
disease, and its accumulation exhibits a rich spatio-temporal pattern that unfolds during the …
Data-driven simulation of network-based tau spreading tailored to individual Alzheimer's patients
Tau tangles in the brain cortex spread along the brain network in distinct patterns among
Alzheimer's patients. We aim to simulate their network-based spreading within the cortex …
Alzheimer's patients. We aim to simulate their network-based spreading within the cortex …
Neuronal activity induces symmetry breaking in neurodegenerative disease spreading
Dynamical systems on networks typically involve several dynamical processes evolving at
different timescales. For instance, in Alzheimer's disease, the spread of toxic protein …
different timescales. For instance, in Alzheimer's disease, the spread of toxic protein …
[HTML][HTML] Two for tau: Automated model discovery reveals two-stage tau aggregation dynamics in Alzheimer's disease
Alzheimer's disease is a neurodegenerative disorder characterized by the presence of
amyloid-β plaques and the accumulation of misfolded tau proteins and neurofibrillary …
amyloid-β plaques and the accumulation of misfolded tau proteins and neurofibrillary …
Exploring tau protein and amyloid-beta propagation: a sensitivity analysis of mathematical models based on biological data
M Corti - arXiv preprint arXiv:2404.14169, 2024 - arxiv.org
Alzheimer's disease is the most common dementia worldwide. Its pathological development
is well known to be connected with the accumulation of two toxic proteins: tau protein and …
is well known to be connected with the accumulation of two toxic proteins: tau protein and …