Next generation gold drugs and probes: chemistry and biomedical applications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …
Metal drugs and the anticancer immune response
B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
Molecular mechanisms and clinical implications of the gold drug auranofin
S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
The gold complex auranofin: new perspectives for cancer therapy
FH Abdalbari, CM Telleria - Discover Oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …
to the lack of long-term treatment options following the standard form of care. New options …
Antitumor effects of carvacrol and thymol: a systematic review
LA Sampaio, LTS Pina, MR Serafini… - Frontiers in …, 2021 - frontiersin.org
Background: It is estimated that one in five people worldwide faces a diagnosis of a
malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural …
malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural …
[HTML][HTML] Metal-and metalloid-based compounds to target and reverse cancer multidrug resistance
Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …
stage of the disease. However, based on their versatile chemistry, metal and metalloid …
[HTML][HTML] Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell …
Auranofin (AF) is an FDA-approved antirheumatic drug with anticancer properties that acts
as a thioredoxin reductase 1 (TrxR) inhibitor. The exact mechanisms through which AF …
as a thioredoxin reductase 1 (TrxR) inhibitor. The exact mechanisms through which AF …
The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …
several cell functions of cancer cells. Several natural products modulate both oxidative …
Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness
T Gamberi, G Chiappetta, T Fiaschi… - Medicinal Research …, 2022 - Wiley Online Library
Auranofin is an oral gold (I) compound, initially developed for the treatment of rheumatoid
arthritis. Currently, Auranofin is under investigation for oncological application within a drug …
arthritis. Currently, Auranofin is under investigation for oncological application within a drug …
Potential anticancer activity of auranofin
T Onodera, I Momose, M Kawada - Chemical and Pharmaceutical …, 2019 - jstage.jst.go.jp
Gold compounds have a long history of use in medicine. Auranofin was developed more
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …