mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Herpes simplex virus cell entry mechanisms: an update

K Madavaraju, R Koganti, I Volety… - Frontiers in cellular …, 2021 - frontiersin.org
Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating
infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and …

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

DR Martinez, A Schäfer, SR Leist, G De la Cruz, A West… - Science, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 and
SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against …

mRNA vaccine: a potential therapeutic strategy

Y Wang, Z Zhang, J Luo, X Han, Y Wei, X Wei - Molecular cancer, 2021 - Springer
Abstract mRNA vaccines have tremendous potential to fight against cancer and viral
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …

40 years after the registration of acyclovir: do we need new anti-herpetic drugs?

A Majewska, B Mlynarczyk-Bonikowska - International journal of …, 2022 - mdpi.com
Herpes simplex virus types 1 and 2 HSV1 and 2, namely varicella-zoster VZV and
cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in …

[HTML][HTML] mRNA vaccines: Past, present, future

M Karam, G Daoud - Asian journal of pharmaceutical sciences, 2022 - Elsevier
Abstract mRNA vaccines have emerged as promising alternative platforms to conventional
vaccines. Their ease of production, low cost, safety profile and high potency render them …

mRNA vaccines for infectious diseases—advances, challenges and opportunities

N Pardi, F Krammer - Nature Reviews Drug Discovery, 2024 - nature.com
The concept of mRNA-based vaccines emerged more than three decades ago.
Groundbreaking discoveries and technological advancements over the past 20 years have …

Lipid nanoparticle delivery systems to enable mRNA-based therapeutics

SC Semple, R Leone, CJ Barbosa, YK Tam, PJC Lin - Pharmaceutics, 2022 - mdpi.com
The world raced to develop vaccines to protect against the rapid spread of SARS-CoV-2
infection upon the recognition of COVID-19 as a global pandemic. A broad spectrum of …

The importance of RNA-based vaccines in the fight against COVID-19: an overview

BAS Machado, KVS Hodel, LMS Fonseca… - Vaccines, 2021 - mdpi.com
In recent years, vaccine development using ribonucleic acid (RNA) has become the most
promising and studied approach to produce safe and effective new vaccines, not only for …

Synthetic modified messenger RNA for therapeutic applications

M Gao, Q Zhang, XH Feng, J Liu - Acta biomaterialia, 2021 - Elsevier
Synthetic modified messenger RNA (mRNA) has manifested great potentials for therapeutic
applications such as vaccines and gene therapies, with the recent mRNA vaccines for global …