Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Sequestration of G protein-coupled receptors from the cell surface is a commonly observed
phenomenon following agonist-stimulation. This process is now believed to be important for …

For decades, it has been generally proposed that a given receptor always interacts with a
particular GTP-binding protein (G-protein) or with multiple G-proteins within one family …

Endothelin-1 (ET-1) is a major regulator of vascular function, acting via both endothelin
receptor type A (ETAR) and type B (ETBR). Although the role of ETAR in vascular smooth …

δ and μ opioid receptors are homologous G protein-coupled receptors that are differentially
sorted between divergent degradative and recycling membrane pathways following agonist …

The endothelin (ET) system consists of two G protein coupled–receptors (GPCRs), ET type A
receptor (ETAR) and ET type B receptor (ETBR), and three endogenous ligands, ET-1, ET-2 …

The endogenous endothelin (ET) peptides participate in a remarkable variety of pain-
relatedprocesses. Pain that is elevated by inflammation, by skin incision, by cancer, during a …

Endothelins are thought to act through two specific, plasmalemmal G protein-coupled
receptor subtypes, ET AR and ET B R. However, in subfractionated cardiac membranes, ET …

Previous studies have demonstrated that the interaction of the angiotensin II type 1A
receptor (AT 1A R) carboxyl-terminal tail with Rab5a may modulate Rab5a activity, leading …

Hepatocyte growth factor‐regulated tyrosine kinase substrate (Hrs) is well known to
terminate cell signaling by sorting activated receptors to the MVB/lysosomal pathway. Here …