INTRODUCTION Although hundreds of organic reactions have been validated under
consensus prebiotic conditions, we still have only a fragmentary understanding of how these …

Cyclic guanosine monophosphate–adenosine monophosphate (GMP-AMP)(cGAS), a
cytosolic DNA sensor, plays an important role in the type I interferon response. DNA from …

Limited presence of hCA IX in normal physiological tissues and their overexpression only in
solid hypoxic tumors made this isoform excellent possible target for developing new …

Ovarian cancer (OC) is the most deadly gynecological cancer and unlike most other
neoplasms, survival rates for OC have not significantly improved in recent decades. We …

Abstract Series of 4-amino-6-(arylamino)-1, 3, 5-triazine-2-carbohydrazides (3a–e) and N′-
phenyl-4, 6-bis (arylamino)-1, 3, 5-triazine-2-carbohydrazides (6a–e), for ease of readership …

In this minireview, we discuss the chemistry of biguanides and their applications in catalysis.
We present their super basicity as a consequence of their structure, the most efficient ways …

Twelve derivatives of biguanide-derived 1, 3, 5-triazines, a promising class of anticancer
agent, were synthesised and evaluated for their anticancer activity against two colorectal …

1, 3, 5-Triazine-based compounds form a privileged class of compounds in the medicinal
chemistry field as they are versatile synthetic scaffolds possessing wide spectra of biological …

Abstract The 1, 3, 5-triazine scaffold is known for its versatile biological activities especially
as an anticancer agent, but a limitation of 1, 3, 5-triazine is the ability to reach cancer cells …

Nearly 20 years ago, mitochondria were mistakenly considered only as the home production
of energy molecule, adenosine triphosphate. However, a large growing research body has …