Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

Glycosylation is a very frequent and functionally important post-translational protein
modification that undergoes profound changes in cancer. Growth and death factor receptors …

Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell
surface receptors, most of which are heavily glycosylated. This review discusses receptor …

Background Body traits are generally controlled by several genes in vertebrates (ie
polygenes), which in turn make them difficult to identify through association mapping …

Fucosyltransferase 8 (FUT8) encodes a Golgi-localized α1, 6 fucosyltransferase that is
essential for transferring the monosaccharide fucose into N-linked glycoproteins, a process …

The maternal milk glycobiome is crucial for shaping the gut microbiota of infants. Although
high core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is a general feature of human …

α1, 6-Fucosyltransferase (Fut8) catalyzes the transfer of fucose to the innermost GlcNAc
residue of N-glycan to form core fucosylation. Our previous studies showed that …

Notch is a cell-surface receptor that controls cell-fate decisions and is regulated by O-
glycans attached to epidermal growth factor-like (EGF) repeats in its extracellular domain …

Previously, we reported that α1, 6-fucosyltransferase (Fut8)-deficient (Fut8−/−) mice exhibit
emphysema-like changes in the lung and severe growth retardation due to dysregulation of …

Core fucosylation, a posttranslational modification of N-glycans, modifies several growth
factor receptors and impacts on their ligand binding affinity. Core-fucose-deficient mice …