Coumarin-based derivatives with potential anti-HIV activity
Z Xu, Q Chen, Y Zhang, C Liang - Fitoterapia, 2021 - Elsevier
Acquired immunodeficiency syndrome (AIDS), as a result of human immunodeficiency virus
(HIV) infection which leads to severe suppression of immune functions, is an enormous …
(HIV) infection which leads to severe suppression of immune functions, is an enormous …
Coumarin: An emerging antiviral agent
Viral infections are responsible for many illnesses, and recent outbreaks have raised public
health concerns. Despite the availability of many antiviral drugs, they are often unsuccessful …
health concerns. Despite the availability of many antiviral drugs, they are often unsuccessful …
Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for …
Our present work demonstrates the successful design and synthesis of a new class of
compounds based upon a multitargeted directed ligand design approach to discover new …
compounds based upon a multitargeted directed ligand design approach to discover new …
Design and development of benzyl piperazine linked 5-phenyl-1, 2, 4-triazole-3-thione conjugates as potential agents to combat Alzheimer's disease
Our present work demonstrates the molecular hybridization-assisted design, synthesis, and
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …
[HTML][HTML] HIV-1 Reverse Transcriptase/Integrase dual inhibitors: A review of recent advances and structure-activity relationship studies
M Mahboubi-Rabbani, M Abbasi… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
The significant threat to humanity is HIV infection, and it is uncertain whether a definitive
treatment or a safe HIV vaccine is. HIV-1 is continually evolving and resistant to commonly …
treatment or a safe HIV vaccine is. HIV-1 is continually evolving and resistant to commonly …
Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat …
A series of some novel compounds (SD-1–17) were designed following a molecular
hybridization approach, synthesized, and biologically tested for hAChE, hBChE, hBACE-1 …
hybridization approach, synthesized, and biologically tested for hAChE, hBChE, hBACE-1 …
Molecular docking studies of synthesized pyridazinone scaffolds as non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Abstract Pyridazinone derivatives, 6-aryl-pyridazinone (2a–f) and 2-(N-substituted)-6-aryl-
pyridazinone (3a–h) derivatives were synthesized and assessed for cytotoxicity action using …
pyridazinone (3a–h) derivatives were synthesized and assessed for cytotoxicity action using …
Design, synthesis, molecular modeling and anti-HIV assay of novel quinazolinone incorporated coumarin derivatives
M Safakish, Z Hajimahdi, MR Aghasadeghi… - Current HIV …, 2020 - ingentaconnect.com
Background: The emergence of drug-resistant viral strains has created the need for the
development of novel anti-HIV agents with a diverse structure that targets key enzymes in …
development of novel anti-HIV agents with a diverse structure that targets key enzymes in …
[HTML][HTML] The SARS-Cov-2 Proliferation blocked by a novel and potent main protease inhibitor via computer-aided drug design
S Shayan, S Jamaran, RH Askandar… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
The recent prevalence of novel “coronavirus disease 2019” has expanded quickly globally,
causing a universal pandemic. Herein, an effort was constructed to design a potent drug to …
causing a universal pandemic. Herein, an effort was constructed to design a potent drug to …
In silico studies and biological evaluation of chalcone-based 1, 5-benzothiazepines as new potential H1N1 neuraminidase inhibitors
Benzothiazepines are benzo-fused seven-membered heterocycles. Due to their biological
activities against a wide spectrum of targets, they are of particular interest for drug discovery …
activities against a wide spectrum of targets, they are of particular interest for drug discovery …