Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Protein misfolding in neurodegenerative diseases: implications and strategies
P Sweeney, H Park, M Baumann, J Dunlop… - Translational …, 2017 - Springer
A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse …
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse …
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev… - Proceedings of the …, 2017 - National Acad Sciences
The self-assembly of α-synuclein is closely associated with Parkinson's disease and related
syndromes. We show that squalamine, a natural product with known anticancer and antiviral …
syndromes. We show that squalamine, a natural product with known anticancer and antiviral …
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons, a
process that current therapeutic approaches cannot prevent. In PD, the typical pathological …
process that current therapeutic approaches cannot prevent. In PD, the typical pathological …
Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases
Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …
diseases, and achieve increased longevity. Unfortunately, increased longevity is …
Huntington's disease: underlying molecular mechanisms and emerging concepts
J Labbadia, RI Morimoto - Trends in biochemical sciences, 2013 - cell.com
Huntington's disease (HD) is a progressive neurodegenerative disorder for which no
disease modifying treatments exist. Many molecular changes and cellular consequences …
disease modifying treatments exist. Many molecular changes and cellular consequences …
Cellular strategies of protein quality control
B Chen, M Retzlaff, T Roos… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Eukaryotic cells must contend with a continuous stream of misfolded proteins that
compromise the cellular protein homeostasis balance and jeopardize cell viability. An …
compromise the cellular protein homeostasis balance and jeopardize cell viability. An …
Aging as an event of proteostasis collapse
Aging cells accumulate damaged and misfolded proteins through a functional decline in
their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and …
their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and …
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
Protein damage contributes prominently to cellular aging. To address whether this occurs at
a specific period during aging or accumulates gradually, we monitored the biochemical …
a specific period during aging or accumulates gradually, we monitored the biochemical …
The structural biochemistry of the superoxide dismutases
The discovery of superoxide dismutases (SODs), which convert superoxide radicals to
molecular oxygen and hydrogen peroxide, has been termed the most important discovery of …
molecular oxygen and hydrogen peroxide, has been termed the most important discovery of …