Metformin and cancer: solutions to a real-world evidence failure

OHY Yu, S Suissa - Diabetes care, 2023 - Am Diabetes Assoc
The quest to repurpose metformin, an antidiabetes drug, as an agent for cancer prevention
and treatment, which began in 2005 with an observational study that reported a reduction in …

Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells

A Yeşildağ, HT Kızıloğlu, E Dirican, E Erbaş… - Biological trace element …, 2024 - Springer
Metformin is commonly prescribed to people with diabetes. Metformin has been shown in
previous studies to be able to prevent the growth of cancer cells. This study aims to …

Preoperative metabolic syndrome and prognosis after pancreatectomy for pancreatic cancer: A retrospective study

F Gu, X Shen, Z Wang, Z Xie, N Ke - World Journal of Surgery, 2024 - Wiley Online Library
Background We conducted a retrospective study to investigate the impact of metabolic
syndrome (MetS), its individual components, and the number of metabolic risk factors on the …

[HTML][HTML] Survival benefit of metformin use according to cancer diagnosis in diabetic patients with metabolic syndrome

JS Park, SJ Moon, HS Park, SH Cho - Preventive Medicine Reports, 2024 - Elsevier
Abstract Background Metabolic syndrome (MetSyn) is a disease cluster causing
cardiovascular disease, cancer, and high mortality. Metformin is the most common …

Metronomic cyclophosphamide and metformin inhibited tumor growth and repopulated tumor-infiltrating lymphocytes in an experimental carcinoma model

HM Zaki, KM Ali, MYY Abd Allah, AM Abouelnaga… - BMC Research …, 2024 - Springer
Metformin is a widely used antidiabetic biguanide. Retrospective data demonstrated the
association of metformin use with survival benefit in multiple tumor types. Interest in …

Association of metformin and statin uses with the prognosis of colon cancer: a meta-analysis

Y Xu, H Che, J Liu, P Ye - European Journal of Cancer Prevention, 2024 - journals.lww.com
Background Metformin and statins are commonly used globally for the treatment of type 2
diabetes mellitus and dyslipidemia, respectively. Recently, multiple novel pathways have …

二甲双胍在恶性肿瘤治疗中的研究进展

段雪玉, 廖彬彬, 李蕾, 张鼎才, 陈瑞祥… - 中国 …, 2024 - journal.china-pharmacy.com
近年来二甲双胍潜在的抗肿瘤效果在肿瘤治疗领域引起了广泛关注. 本文综述了二甲双胍在恶性
肿瘤治疗中的研究进展, 发现其在消化系统恶性肿瘤(胆道癌, 胃癌, 食管癌, 结直肠癌, 胰腺癌 …

Metformin Reduces Tumor Growth in a Murine Flank Schwannoma Model

S Manickavel, Y Hartman, A Burns… - Otology & …, 2023 - journals.lww.com
Background There have been reported associations between patients with VS prescribed
metformin and decreased tumor volumetric growth. Aspirin has also been associated with …

Research progress on metformin in the treatment for malignant tumors

D Xueyu, L Binbin, LI Lei, Z Dingcai… - China …, 2024 - journal.china-pharmacy.com
In recent years, the potential anti-tumor effects of metformin have attracted widespread
attention in the field of cancer treatment. This article summarizes the research progress of …