For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

The management of retinoblastoma, the most common intraocular malignancy in children,
has changed drastically over the last decade. Landmark developments in local drug …

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

Background To evaluate the efficacy, complications, and clinical characteristics, including
the ocular toxicity, of intravitreal melphalan (IVM) treatment for vitreous seeding in Chinese …

Retinoblastoma is the most common primary intraocular malignancy in infancy with a
metastases-related death risk. However, a safe and convenient treatment without …

Background: Active vitreous seeds in eyes with retinoblastoma (Rb) adversely affects the
treatment outcome. This study aimed to investigate the safety and efficacy of intravitreal …

Purpose: To use our intra-arterial chemotherapy (IAC) rabbit model to assess the impact of
IAC procedure, drug, dose, and choice of technique on ocular structure and function, to …

Purpose: To review preclinical and clinical pharmacokinetic studies of the three most
important chemotherapy drugs used for intraocular retinoblastoma and the contribution of …

Host defense peptides represent an important component of innate immunity. In this work,
we report the anticancer properties of a panel of hyper-charged wholly cationic antimicrobial …

Enhancer of zeste homolog 2 (EZH2) has been reported selectively expressed in postnatal
human retinoblastoma (RB). While, the contribution of EZH2 in progression of RB and its …