Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect

V Ejigah, O Owoseni, P Bataille-Backer, OD Ogundipe… - Polymers, 2022 - mdpi.com
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …

Magnetic particle imaging: current and future applications, magnetic nanoparticle synthesis methods and safety measures

C Billings, M Langley, G Warrington, F Mashali… - International Journal of …, 2021 - mdpi.com
Magnetic nanoparticles (MNPs) have a wide range of applications; an area of particular
interest is magnetic particle imaging (MPI). MPI is an imaging modality that utilizes …

Towards a better understanding of the complexities of myalgic encephalomyelitis/chronic fatigue syndrome and long COVID

WP Tate, MOM Walker, K Peppercorn… - International Journal of …, 2023 - mdpi.com
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex condition
arising in susceptible people, predominantly following viral infection, but also other stressful …

Role of the locus coeruleus and basal forebrain in arousal and attention

EB Maness, JA Burk, JT McKenna, FL Schiffino… - Brain research …, 2022 - Elsevier
Experimental evidence has implicated multiple neurotransmitter systems in either the direct
or indirect modulation of cortical arousal and attention circuitry. In this review, we selectively …

Development of a redox-label-doped molecularly imprinted polymer on β-cyclodextrin/reduced graphene oxide for electrochemical detection of a stress biomarker

A Goyal, T Sakata - ACS omega, 2022 - ACS Publications
Cortisol is a major stress biomarker involved in the regulation of metabolic and immune
responses. Readily accessible assays with sufficient quantitative and temporal resolution …

Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring

V Vignesh, B Castro-Dominguez, TD James… - ACS …, 2024 - ACS Publications
The hormone cortisol, released as the end-product of the hypothalamic-pituitary-adrenal
(HPA) axis, has a well-characterized circadian rhythm that enables an allostatic response to …

TGF-β-Based Therapies for Treating Ocular Surface Disorders

FT Ogata, S Verma, VJ Coulson-Thomas, TF Gesteira - Cells, 2024 - mdpi.com
The cornea is continuously exposed to injuries, ranging from minor scratches to deep
traumas. An effective healing mechanism is crucial for the cornea to restore its structure and …

Circadian rhythm in systemic autoimmune conditions: Potential of chrono-immunology in clinical practice: A narrative review

WA Awuah, H Huang, J Kalmanovich, A Mehta… - Medicine, 2023 - journals.lww.com
The circadian rhythm (CR) is a fundamental biological process regulated by the Earth's
rotation and solar cycles. It plays a critical role in various bodily functions, and its …

Genome integrity and neurological disease

EEM Scheijen, DM Wilson III - International Journal of Molecular Sciences, 2022 - mdpi.com
Neurological complications directly impact the lives of hundreds of millions of people
worldwide. While the precise molecular mechanisms that underlie neuronal cell loss remain …

Pathophysiological link between insulin resistance and adrenal incidentalomas

JA Higgs, AP Quinn, KD Seely, Z Richards… - International Journal of …, 2022 - mdpi.com
Adrenal incidentalomas are incidentally discovered adrenal masses greater than one
centimeter in diameter. An association between insulin resistance and adrenal …